The size of the study sample was not predetermined, but it was based on enrolling patients in the study sites. Comparisons of the percentage change in the frequency of motor seizures were made with a Mann-Whitney U test.
Cannabidiol is a potent inhibitor of CYP3A4 and CYP2C19 (isoenzyme P450 for the elimination of N-desmethyl clobazam CBD Gummies, the long-acting active metabolite of clobazam) in addition to other CYP isoenzymes, with the potential to increase serum concentrations of antiepileptic drugs basal levels and their active metabolites.
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